Internship: Autonomous Downstream Purification for …, Corsier-sur-Vevey

Start date: August / September

Duration: 6-12 months

Location: Corsier-sur-Vevey

Role Level: Internship

Your role

As a member of the Global Drug Substance Development, you will work with a group of motivated scientists who are committed to developing and implementing solutions to support the development of new biological therapeutics processes.

An innovative autonomous end-to-end monoclonal antibody platform is being developed to integrate perfusion cell culture with continuous downstream processing. Perfusion culture enables sustained high-density cell culture with continuous product harvest, generating a steady stream of cell-free culture fluid suitable for direct integration with automated purification operations.

You will work on establishing this autonomous system to enable rapid, high-throughput material generation for early-stage development activities, significantly accelerating timelines and reducing manual intervention in the production of monoclonal antibody samples for process development and characterization studies.

Your mission will focus on automating the critical downstream purification sequence, specifically:

Affinity capture chromatography onÄKTA systems using Protein A columns for monoclonal antibody capture.

Automated low‑pH viral inactivation to ensure viral safety.

Depth filtration for particle removal.

You will design and execute experiments to characterize individual unit operations, optimize their integration into a continuous workflow, and demonstrate that the autonomous platform consistently produces high-quality monoclonal antibody material suitable for development studies.

You will be trained to be autonomous, and you will have the opportunity to present your work during various meetings.

Your profile

Master/engineer student in biotechnology related fields

Currently studying

Highly motivated and autonomous

Ability to conceptualize, solve complex challenges, and communicate about your project

Great team spirit

Previous experience in DSP and/or Automation is a plus

Python skills is a plus

Good written and oral knowledge in English, French is a plus

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