Topic Lead for Structure Elucidation and Mass Spectrometry, Basel

Opportunity

As Topic Lead for Small Molecule Structure Elucidation you will act as an analytical detective. You will use state-of-the-art high-resolution LC-MS and GC-MS systems to solve complex structural puzzles, identifying and characterizing unknown impurities in our small molecule, oligonucleotide, and peptide portfolio.You will serve as topic lead and subject matter expert for structure elucidation, maintaining overall oversight on all structure elucidation requests and collaborating closely with team members. You will solve analytical challenges by independently designing and executing hands‑on lab experiments for the structure elucidation of unknown impurities from e.g. process development, forced degradation studies, and troubleshooting activities.You will apply expertise in cutting‑edge techniques including qualitative LC‑HRMS, 2D‑LC‑HRMS, and GC‑HRMS to analyze complex drug substances and drug products. You will critically evaluate and interpret complex analytical data and provide clear, concise conclusions in English that guide project teams and support regulatory filings.You will sense future needs and actively identify opportunities to enhance workflows, evaluate new software tools, and contribute to the team’s ongoing development. You will act as an enabler by removing barriers and creating a work environment where every team member can be successful. You will proactively partner with project leads and stakeholders across functions, ensuring analytical insights are directly communicated, understood, and integrated into project decisions.Who You Are

You are a passionate structure elucidation expert with people leadership skills who finds deep satisfaction in solving complex structural puzzles and sharing your knowledge. You thrive in a collaborative, high‑tech environment and are motivated by the direct impact your work has on developing new medicines.Qualifications

Higher education (Master’s or PhD in Chemistry, Biochemistry, or related field) or an apprenticeship as a laboratory technician with a minimum of 5 years hands‑on experience in structure elucidation using LC‑HRMS and proven leadership skills. Proven, in‑depth experience in interpreting high‑resolution MS and MS/MS spectra for small molecules, peptides, or oligonucleotides.Hands‑on skills in developing and optimizing chromatographic (HPLC, GC) and mass spectrometry methods. Pragmatic, proactive, solution‑oriented, and accurate work style that balances independent project responsibilities with active team collaboration. Excellent communication skills and fluency in English; proficiency in German is a plus.Interest in digital innovation, with exposure to tools like GeneData Expressionist®, ACD/Labs or programming languages (Python, JavaScript). Practical experience with maintenance and troubleshooting of HPLC, GC and MS instrumentation, as well as hands‑on experience with 2D‑LC‑MS and preparative HPLC.Comfortable and experienced working with MS instruments and software from various vendors. Equal Opportunity Statement

Roche is an Equal Opportunity Employer.

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