Intern– Cell Biology (6 Month Contract), Basel

Overview Monte Rosa Therapeutics, an industry leader in targeted protein degradation (TPD), is seeking a passionate intern in Cell Biology to help us eliminate disease-causing proteins that were previously considered undruggable through our novel and exciting TPD platform. You will work closely with experienced scientists who will direct and mentor you on your project, while also exposing you to other drug discovery projects and involving you in solving complex biological questions. You will be joining a diverse, thoughtful, fun and collaborative environment that emphasizes teamwork and putting people first! This role is slated for a September 2026 or sonner start.

Responsibilities

Develop and validate innovative cellular assays to measure proximity of E3 ligases to target proteins and enhance the company’s technology portfolio

Design and implement assay optimization strategies to maximize signal intensity, specificity, robustness and reproducibility

Collect, analyze and interpret dose response / screening data, formulate scientific hypotheses to iteratively identify and modify critical assay parameters

Collaborate with different functions within the company, attend and present your data at team and project meetings

All learnings will be applied to our Discovery pipeline for the identification of novel degraders for highly relevant targets

Qualifications

Our preference is for a student currently enrolled, or having recently completed, a master’s degree program in Cell Biology, Molecular Biology, Biochemistry or a similar life science field

Previous experience with mammalian cell culture and working in a sterile environment is essential

Know-how in conventional cell biology and molecular biology techniques (e.g. plasmid transfection, immunoassays, viability assays, cloning and sequencing)

Experience in microplate-based cellular assays and lab automation (e.g. liquid handlers) is a plus

Familiarity with protein proximity assays (e.g. Split-protein systems / protein-fragment complementation, NanoBRET, NanoBiT, proximity labeling, etc) is an advantage, but not required

You are a fast learner and enjoy working in a team-based environment

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