Post Doctorate Scientist in Intestinal Inflammation - at …, Basel

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The Position The Institute of Human Biology (IHB), embedded within Roche’s Pharma Research and Early Development (pRED) Division, is a leading research institute focused on accelerating the development of transformative medicines. It specializes in developing novel and robust human model systems that functionally resemble human physiology and disease. By bridging thegap between academic discovery and industrial application, IHB facilitates the rapid translation of groundbreaking science into patient-focused solutions.

The Opportunity As a

Post Doctorate Scientist in Intestinal Inflammation

at the IHB, you will focus on deconstructing inflammatory bowel disease pathobiology using advanced human model systems. The duration of the position is initially set for two years, with the possibility of extension. You will be based in Basel, Switzerland. The start date of this position is 1 st

September 2026.

Responsibilities

Drive a project to create high fidelity in vitro models of inflammatory bowel disease, by combining primary human samples, organoids, tissue‑resident/infiltrating immune cells and microfabrication technology to recreate the cellular environment of the diseased intestine.

Collaborate with multidisciplinary teams to improve the ability of in vitro models to 1) recapitulate inflammatory disease, 2) understand the underlying molecular and cellular mechanisms, 3) identify strategies to mitigate these pathogenic pathways.

Generate top quality results for high‑impact publications.

Who you are You are a scientist with a PhD in the field of immunology and a profound understanding of mucosal biology. Furthermore, you have great interpersonal and communication skills. Your experience and investigative attitude allow you to collaboratively design, perform, and interpret experiments, and build on experimental observations to drive the research project towards meaningful and impactful biological insight. Fundamental to this position is a proactive mindset and a willingness to learn, explore and master new techniques and technologies. You have been actively engaged in scientific research continuously since your PhD and are ready to start this postdoctoral position no later than 4 years after your PhD.

Desired Experience

Deep understanding of the properties and phenotypes of mucosal immune cells.

Experience in handling, manipulating and phenotyping myeloid cells.

Handling of large data, including the generation, analysis and interpretation of scRNA‑seq and spatial omics.

Handling of human intestinal tissue samples, particularly inflammatory bowel disease samples.

3D culture.

Ready to drive the future of mucosal biology? Apply now to join our team in Basel! The application needs to include a CV with a publication list, as well as a cover letter detailing your motivation for applying.

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Roche is an Equal Opportunity Employer.

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